The main area of research is directed towards an understanding of the mechanisms of
bone growth in children, notably the interactions between extracellular matrix and
cytokines. In addition to an investigation of normal growth, a genetic disorder
affecting extracellular matrix degradation (mucopolysaccharidoses) is under
examination. On a more clinical level, research projects to target therapy regimens
to the sites of pathology in the mucopolysaccharidoses are underway. Specific projects
include the evaluation of enzyme replacement therapy on skeletal and CNS pathology and
the development of improved diagnostic assays for the mucopolysaccharidoses. Through
collaboration with Dr N.L. Fazzalari (IMVS, Adelaide) and Dr R.W. Byard
(Histopathology, WCH) an investigation into the role of primary growth abnormality
in Sudden Infant Death Syndrome (SIDS) is ongoing.
Pathophysiology research is funded by grants from the NH&MRC program grant on
Lysosomal Storage Disorders, the Women's and Children's Hospital Foundation, the
Bone Growth Foundation, the Adelaide and Joint Research foundation and the SIDS
Research foundation
Contact:
Dr Sharon Byers,
Department of Chemical Pathology,
Women's and Children's Hospital,
72 King William Rd.,
North Adelaide,
South Australia 5006
Australia
Telephone: +61 (0)8 8161 7093
Facsimile: +61 (0)8 8161 7100
Email: sharon.byers@adelaide.edu.au
